Quantification of penicillin-G and procaine in equine urine and plasma using high-performance liquid chromatography |
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| Authors: | Y Luo B McNamara MA Fennell DC Teleis L May J Rudy AO Watson CE Uboh LR Soma |
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| Institution: | aUniversity of Pennsylvania, School of Veterinary Medicine, New Bolton Center Campus, Kennett Square, Philadelphia, PA 19348, USA;bPA Equine Toxicology and Research Laboratory, West Chester University, Department of Chemistry, West Chester, PA 19383, USA |
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| Abstract: | A rapid and sensitive method for the extraction and quantification of penicillin-G and procaine in horse urine and plasma samples has been successfully developed. The method involves the use of solid-phase extraction (SPE) for penicillin-G, liquid–liquid extraction (LLE) for procaine, and high-performance liquid chromatography (HPLC) for the quantification of penicillin-G and procaine. The new method described here has been successfully applied in the pharmacokinetic studies of procaine, penicillin-G and procaine–penicillin-G administrations in the horse. |
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| Keywords: | Penicillin-G Procaine |
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