Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA |
| |
Authors: | Liao Chenzhong Karki Rajeshri G Marchand Christophe Pommier Yves Nicklaus Marc C |
| |
Institution: | Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS, Frederick, MD 21702, USA. |
| |
Abstract: | To address the absence of experimental data on the full-length structure of HIV-1 integrase and the way it binds to viral and human DNA, we had previously Karki, R. G.; Tang, Y.; Burke, T. R., Jr.; Nicklaus, M. C. J. Comput. Aided Mol. Des.2004, 18, 739] constructed models of full-length HIV-1 integrase complexed with models of viral and human DNA. Here we describe the discovery of novel HIV-1 integrase strand transfer inhibitors based on one of these models. Virtual screening methods including docking and filtering by predicted ADME/Tox properties yielded several microM level inhibitors of the strand transfer reaction catalyzed by wild-type HIV-1 integrase. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|