|
|||||
|
|
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists |
|
| Authors: | Pinkerton Anthony B Huang Dehua Cube Rowena V Hutchinson John H Struthers Mary Ayala Julia M Vicario Pasquale P Patel Sima R Wisniewski Thomas DeMartino Julie A Vernier Jean-Michel |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, MRLSDB2, 3535 General Atomics Court, San Diego, CA 92121, USA. apinkerton@kalypsys.com |
| Abstract: | We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM). |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |