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Diaryl substituted pyrazoles as potent CCR2 receptor antagonists |
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| Authors: | Pinkerton Anthony B Huang Dehua Cube Rowena V Hutchinson John H Struthers Mary Ayala Julia M Vicario Pasquale P Patel Sima R Wisniewski Thomas DeMartino Julie A Vernier Jean-Michel |
| Institution: | Department of Medicinal Chemistry, Merck Research Laboratories, MRLSDB2, 3535 General Atomics Court, San Diego, CA 92121, USA. apinkerton@kalypsys.com |
| Abstract: | We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM). |
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