Mutagenicities of nitrofuran derivatives on a bacterial tester strain with an R factor plasmid |
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| Affiliation: | 1. Department of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, NJ 08854, United States;2. Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States;3. Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, United States;4. Department of Environmental Health Science, New York Medical College, Valhalla, NY 10595, United States |
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| Abstract: | Many nitrofuran derivatives are known to be mutagenic on Escherichia coli WP2 but not on Salmonella typhimurium TA1535, TA1536, TA1537 or TA1538. Ames and coworkers recently obtained a new tester strain of S. typhimurium, TA100, by putting an R factor plasmid, pKM101, into TA1535. We found that all the mutagenic nitrofuran derivatives previously found to be mutagenic on E. coli WP2 were mutagenic on this new strain (TA100). |
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