Effect of cytochalasin B on the surface of neuroepithelial cells of the chick embryo |
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| Affiliation: | 1. Consiglio Nazionale delle Ricerche, Istituto di Ricerca Sulle Acque, Largo Tonolli 50, 28922 Verbania Pallanza VB, Italy;2. Consiglio Nazionale delle Ricerche, Istituto per la Bioeconomia, Via Madonna del Piano 10, 50019 Sesto Fiorentino FI, Italy;1. National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Ropewalk House, 113 The Ropewalk, Nottingham, NG1 5DU, United Kingdom;2. Otology and Hearing Group, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, United Kingdom;3. Medical Research Council (MRC) Institute of Hearing Research, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom;4. Nottingham University Hospitals NHS Trust, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, United Kingdom;1. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran;2. Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran;3. Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran;4. Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran;5. Department of Biogeosciences, Scientific Research Center, Soran University, Soran, Kurdistan Region, Iraq;6. Department of Pathology, Shahrekord University of Medical Sciences, Shahrekord, Iran;7. Department of Immunology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran;1. Servicio de Cirugía General, Hospital Clínico Universitario de Valencia, Valencia, España;2. Facultad de Medicina, Universitat de València, Valencia, España;3. Servicio de Ginecología, Hospital NisaVirgen del Consuelo, Valencia, España;4. Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante, España;5. Servicio de Anatomía Patológica, Hospital Clínico Universitario de Valencia, Valencia, España |
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| Abstract: | Neuroepithelial cells of young chick embryos, exposed in vitro for 1.5 and 13hr to cytochalasin B (5μg/ml) and examined by scanning electron microscopy, show changes in their surface morphology. The cell surface loses its cytoplasmic projections, its ruffle appearance and acquires a great number of cavities. These effects of the drug are not reversible after 4hr incubation on control media. Our results show that cytochalasin B does affect the cell surface morphology in our specimens but they give no indication as to manner in which the drug inhibits interkinetic nuclear migration. |
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