Chromosome damage induced by semicarbazide in spermatocytes of a grasshopper |
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| Affiliation: | 1. Basic Medical and Pharmacy College, Jinggangshan University, Ji''an, 343009, Jiangxi, China;2. School of Pharmacy, Liaocheng University, LiaoCheng, 252059, Shandong, China;3. College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi, China;1. Department of Biology, Emory University, Atlanta, GA 30322, USA;2. Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA |
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| Abstract: | Semicarbazide hydrochloride (0.1 M in glass-distilled water), on injection, showed mutagenic action on the spermatocyte chromosomes of the grasshopper, Spathosternum prasiniferum. Aberrations such as chromatid and chromosome breaks, translocations, fragments and bridges were encountered. The sex chromosome and the long autosomes were affected. Semicarbazide, perhaps, reacts with DNA and the chromosome in a way similar to that of hydroxylamine and hydrazines. |
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