Evolution of LDH isozymes during programmed cell death |
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| Affiliation: | 1. Department of Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Rochester, N.Y. 14642, U.S.A.;2. Department of Chemistry, Skidmore College, Saratoga Springs, N.Y. 12866, U.S.A.;3. Department of Biological Sciences, St. John''s University, Grand Central and Utopia Parkways, Jamaica, N.Y. 11439, U.S.A.;1. North Dakota State University, United States;2. USDA-ARS, United States |
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| Abstract: | - 1.1. Lactic dehydrogenase dehydrogenase isozymes and other respiratory enzymes were studied in degenerating intersegmental muscles of Manduca sexta and Antheraea polyphemus.
- 2.2. Total activities of the different enzymes (isocitric dehydrogenase, malic dehydrogenase, catalase, lactic dehydrogenase) decline at varying rates, starting before the rapid phase of involution.
- 3.3. One isozyme of LDH, an M-type isozyme, increases several-fold during the final three days prior to the emergence of the insect.
- 4.4. The same isozyme appears very transiently or not at all in muscles which do not break down, and is present in degenerating silk glands at the time of their most rapid involution.
- 5.5. The data suggest that limitation of oxidative metabolism plays a role in the involution of the muscles.
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