Possible Hydrogen-Bond interactions of steroid hormones-II. corticosteroids |
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| Affiliation: | 1. Universidad Nacional de San Luis, Facultad de Química, Bioquímica y Farmacia, Instituto de Química de San Luis, INQUISAL (UNSL - CONICET), Chacabuco 917, D5700BWS, San Luis, Argentina;2. Department of Chemistry, Clemson University, Clemson 29634, SC, United States;1. Department of Applied Science and Technology (DISAT), Politecnico of Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy;2. Department of Chemistry and NIS Interdepartmental Centre, University of Torino, via Pietro Giuria 7, 10125 Torino, Italy;3. Molecular Biotechnology and Health Sciences Department, University of Torino, via Quarello 15, 10135 Torino, Italy |
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| Abstract: | For each of the polar functions of the twenty known crystalline structures of corticosteroids, we determine the position of the atoms forming an intermolecular hydrogen bond with the oxygen of the function, so that we can find the preferential positions-relative to the steroid-of the atoms that take part in such bonds. That leads us to an estimate of the distance between the atoms capable of fixing the steroid by O3 and O20 or O21 on the receptor. The determined value is 16.5 Å. We apply the same reasoning to explain the role of the inhibitors. |
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