Metabolism of testosterone in the isolated perfused rat lungs |
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| Affiliation: | 1. Biofilm Research Lab., Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh 202002, India;2. Department of Environment, Geology and Natural Resources, Ball State University, Muncie, IN 47306, USA;1. Research Institute, Centre Testing International Group Co., Ltd., Shenzhen 518000, China;2. Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;3. Shenzhen JL Computational Science and Applied Research Institute, Shenzhen 518110, China;1. Materials Science and Engineering Postgraduate Program, UFPB, 58051-900, João Pessoa, Brazil;2. Materials and Biosystems Laboratory (LAMAB), DEMAT, UFPB, 58051-900, João Pessoa, Brazil;3. Department of Mechanical Engineering, University of Aveiro, 3810-193, Aveiro, Portugal;4. CICECO, Dep. Eng. Materiais e Cerâmica, University of Aveiro, 3810-193, Aveiro, Portugal |
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| Abstract: | The metabolism of [4-14C]-testosterone in the isolated perfused rat lungs was investigated following the administration of the substrate eithervia the pulmonary artery orvia the trachea. After administration of testosterone in the circulating medium, 3.5% of the hormone was metabolized to various unconjugated metabolites during a single passage through the pulmonary circulation. It so seems that the lungs, receiving all the cardiac output, are one of the major sites of androgen catabolism in the rat organism. The major metabolites were 5α- and 5β-androstane-3α,17β-diols and various non-conjugated polar metabolites. After intratracheal instillation, testosterone was rapidly absorbed from rat lungs. Two minutes following installation, 62% of the dose was recovered from the lungs. Two thirds of this was present as metabolites.It is concluded that the lungs have an efficient metabolic capacity towards androgens. The availability of extractable substrate seems to be rate limiting for the pulmonary testosterone metabolism. |
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