Chromosome aberrations in lymphocytes after occupational exposure to lead and cadmium |
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| Affiliation: | 1. National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333;2. Oak Ridge Institute for Science and Education, Oak Ridge 37830, Tennessee, USA;3. National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333;4. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333;1. Department of Internal Medicine, University of Nebraska Medical Center and the VA Nebraska-Western Iowa Health Care System, United States of America;2. Department of Psychology, Midland University, United States of America;3. College of Public Health, University of Nebraska Medical Center, United States of America;4. Department of Psychology, University of Nebraska-Lincoln, United States of America;5. Human Development and Family Science, University of Missouri, United States of America |
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| Abstract: | Chromosomes were analysed in peripheral lymphocytes of 24 workers in a zinc smelting plant who had increased blood levels of lead and cadmium. The number of cells with structural chromosome aberrations was significantly increased as compared with 15 controls. The observed chromosome damage was mainly of the chromatid type (single breaks and exchanges) accompanied by acentric fragments. The observed chromosome aberrations cannot be causally related to cadmium because the workers were additionally exposed to lead and zinc. However, from existing cytogenetic data on heavy metals an effect of cadmium could be well deduced, although possible synergistic effects of several metal compounds, especially under conditions, in vivo, cannot be excluded. |
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