Diacridines: Bifunctional intercalators II. The biological effects of putrescine,spermidine and spermine diacridines on HeLa cells and on the L-1210 and P-388 leukemia cells |
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| Affiliation: | 1. Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Zijingang Campus, Hangzhou 310058, PR China;2. Horticultural Products Cold Chain Logistics Technology and Equipment National-Local Joint Engineering Laboratory, Hangzhou 310058, PR China;3. Zhejiang Provincial Key Laboratory of Integrative Biology of Horticultural Plants, Zhejiang University, Hangzhou 310058, PR China;4. College of Animal Sciences, Zhejiang University, Zijingang Campus, Hangzhou 310058, PR China;1. Department of Physics, Chandigarh University, Gharuan, Mohali,140413, India;2. Department of Applied Sciences, MSIT, C-4, Janakpuri, New Delhi, 110058, India;1. CBI Swedish Cement and Concrete Research Institute, Borås SE-501 15, Sweden;2. SP Technical Research Institute of Sweden, Borås SE-501 15, Sweden;3. SP Technical Research Institute of Sweden, Gothenburg SE-400 22, Sweden;4. Department of Civil and Environmental Engineering, Chalmers University of Technology, Gothenburg 412 96, Sweden;1. Institute of Earth Sciences, University of Iceland, Sturlugata 7, 101 Reykjavik, Iceland;2. Reykjavík Geothermal, Sudurlandsbraut 18, 108 Reykjavík, Iceland;3. Reykjavík Energy, Bæjarháls 1, 110 Reykjavík, Iceland |
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| Abstract: | The effect of putrescine, spermidine and spermine diacridines on the growth of HeLa cells and of P-388 and L-1210 leukemia cells has been evaluated and compared to that of the parent compound, 9-aminoacridine. The diacridines are more effective growth inhibitors than 9-aminoacridine. The primary site of action appears to be the inhibition of RNA synthesis. |
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