Progesterone metabolism by human cornea |
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| Affiliation: | 1. Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50.830 Villanueva de Gállego, Zaragoza, Spain;2. Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain;3. Department of Physiological Sciences, Science Faculty, Stellenbosch University, Stellenbosch, South Africa |
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| Abstract: | Human cornea excised from patients with wounded eyes were incubated in vitro for a 5-day period in the presence of [4-14C]-progesterone. The following C21 steroid metabolites were identified by paper chromatography, derivative formation, and crystallizations to specific activities: 20α-hydroxy-4-pregnen-3-one, 20β-hydroxy-4-pregnen-3-one, and 5α-pregnan-3,20-dione. |
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