Blood pressure and heart rate effects of prostaglandin E2 and F2α produced by intracerebroventricular injections in cats |
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Authors: | Richard A. Gillis John A. Quest Janette Diaz Souza Peter A. Kot Peter W. Ramwell |
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Affiliation: | Department of Pharmacology and Physiology Georgetown University Schools of Medicine and Dentistry Washington, D.C. 20007, U.S.A. |
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Abstract: | Blood pressure and heart rate effects of prostaglandin E2 and F2α were examines after administrating each agent into the left lateral brain ventricle of chloralose-anesthethized cats. Administration of prostaglandin E2 (1 μg) resulted in significant, prolonged increases in arterial pressure (25.7 ± 6.7 mm Hg) and heart rate (19.4 ± 7.7 beats/min). These responses were mimicked when the same dose of prostagland E2 was administered into the restricted to the lateral and third ventricles via cannulation of the cerebral aqueduct, whereas no significant cardiovascular occured with administration into the fourth ventricle. Intravenous injection of prostaglandin E2 resulted in a transient decrease in blood pressure but no change in heart rate. Administration of prostaglandin F2α (1 and 3 μg) into the CNS produced no significant cardiovascular responses. The same was true when prostaglandin F2α was administered by the intravenous route. These results indicate that pronounced cardiovascular effects can be produced by administering prostaglandin E2 but not F2α into the CNSm and that the central site of action of prostaglandin E2 is in the forebrain. |
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