Switching on RNA silencing suppressor activity by restoring argonaute binding to a viral protein |
| |
| Authors: | Szabó Edit Z Manczinger Máté Göblös Anikó Kemény Lajos Lakatos Lóránt |
| |
| Affiliation: | Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary. |
| |
| Abstract: | We found that Sweet potato feathery mottle virus (SPFMV) P1, a close homologue of Sweet potato mild mottle virus P1, did not have any silencing suppressor activity. Remodeling the Argonaute (AGO) binding domain of SPFMV P1 by the introduction of two additional WG/GW motifs converted it to a silencing suppressor with AGO binding capacity. To our knowledge, this is the first instance of the transformation of a viral protein of unknown function to a functional silencing suppressor. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
