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A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies |
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| Authors: | Doria-Rose Nicole A Georgiev Ivelin O'Dell Sijy Chuang Gwo-Yu Staupe Ryan P McLellan Jason S Gorman Jason Pancera Marie Bonsignori Mattia Haynes Barton F Burton Dennis R Koff Wayne C Kwong Peter D Mascola John R |
| Institution: | Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. |
| Abstract: | Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies. |
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