Short- and Long-term Memory are Differentialy Modulated
by Hippocampal Nerve Growth Factor and Fibroblast Growth Factor |
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| Authors: | Roger?Walz Rafael?Roesler Adalisa?Reinke Márcio Rodrigo?Martins Email author" target="_blank">Jo?o?QuevedoEmail author Ivan?Izquierdo |
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| Institution: | (1) Departamento de Medicina, Universidade do Vale do Itajaí, 88302–202 Itajaí, SC, Brazil;(2) Laboratório de Neurofarmacologia Pré-Clínica, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90046–900 Porta Alegre, RS, Brazil;(3) Laboratório de Neurociências, Universidade do Extremo Sul Catarinense, 88806–000 Criciúma, SC, Brazil;(4) Centro de Memória, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035–003 Porto Alegre, RS, Brazil |
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| Abstract: | Rats were implanted with cannulae in the CA1 area of the dorsal hippocampus and trained in one-trial step-down inhibitory avoidance. Two retention tests were carried out in each animal, one at 1.5 h to measure short-term memory (STM) and another at 24 h to measure long-term memory (LTM). The purpose of the present study was to evaluate the modulation on hippocampal nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) on short- and long-term memory. Immediately after training, animals received 5  l of NGF (0.05, 0.5 or 5.0 ng), bFGF (1.25, 12.5 or 125 ng) or saline per side. At the higher dose, NGF blocked STM. In contrast, NGF at dose of 0.5 and 5.0 ng improved LTM. The bFGF infusion at a dose of 125 ng enhanced LTM. However, bFGF did not alter STM. These findings indicate that hippocampal NGF and bFGF modulate STM and LTM in a different manner. |
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| Keywords: | NGF FGF memory consolidation rat |
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