Comparison of EcoRI restriction MHC genes in man and several primate species |
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| Authors: | Anne-Marie Chausse Jean-Yves Muller Jacques Ruffié Gérard Lucotte |
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| Affiliation: | 1. Laboratoire de Génétique Moléculaire du C.N.T.S., 6 rue Alexandre-Cabanel, 75015 Paris, France;2. Laboratoire d''Immunologie Leuco-Plaquettaire du C.N.T.S., 6 rue Alexandre-Cabanel, 75015 Paris, France;3. Laboratoire d'' Anthropologie Physique du Collège de France, 11 place Mercellin Berthelot, 75005 Paris, France |
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| Abstract: | EcoRI restriction fragments of the major histocompatibility complex (MHC) from different primate species and the rat were hybridized using identical conditions with the human HLA 32P probe of Sood. After agarose gel electrophoresis and Southern Blot analysis, all gave a positive autoradiographic signal. The similarity between these species reflects a common genomic structure and conservation of MHC. A tentative arrangement of the different species is proposed according to the similarities in blotting patterns: man, baboon, marmoset, lemurian and rat. |
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| Keywords: | Primates HLA probe MHC genes comparison Southern blots DNA restriction-fragments length |
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