Design and Synthesis of Heterocyclic Conjugated Peptides as Novel Antimicrobial Agents |
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| Authors: | G. P. Suresha K. C. Prakasha K. N. Shiva Kumara Wethroe Kapfo D. Channe Gowda |
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| Affiliation: | (1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India |
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| Abstract: | Antimicrobial peptides have been recognized as a novel class of antibiotics and several candidates are currently in clinical trials. In the present study, new antimicrobial compounds were synthesized by coupling quinazolinone moiety with the fragments of elastin sequences VP, GVP, VGVP and GVGVP. They were evaluated for their antibacterial activity against both gram positive and gram negative bacterial strains. We are here reporting that heterocyclic conjugated tetra peptide and penta peptide showed enhanced antibacterial activity compare to the conventional antimicrobial drugs. |
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| Keywords: | Antimicrobial drugs Heterocyclic conjugated peptides Synthesis |
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