Relationship between the secretor status and the expression of ABH blood group antigenic determinants in human intestinal brush-border membrane hydrolases |
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| Authors: | Nicole Triadou Edith Audran Monique Rousset Alain Zweibaum Rafael Oriol |
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| Affiliation: | 1. Unité de Recherches de Génétique Médicale, INSERM U12, Hôpital des Enfants Malades, France;2. Unité de Recherches sur le Métabolisme et la Différenciation de Cellules en Culture, INSERM U178, France;3. Institut d''Immuno-Biologie, INSERM U20, Hôpital Broussais, Paris France |
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| Abstract: | At least six hydrolases of the human intestinal brush-border membrane bear ABH blood group antigenic determinants related to the erythrocyte phenotype: the intestinal glycoproteins of blood group A and B subjects express A or B determinants, respectively, while blood group O subjects express the H determinant identified with Ulex europaeus lectin I. These expressions are under the control of the secretor gene: ABH antigens were not detected in the hydrolases of non-secretor subjects. |
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| Keywords: | Hydrolase Brush-border membrane Blood group antigen ABH antigen Secretor gene |
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