Effects of peptides, with emphasis on feeding, pain, and behavior A 5-year (1999-2003) review of publications in Peptides |
| |
Authors: | Yu Yongmei Jawa Ali Pan Weihong Kastin Abba J |
| |
Institution: | aPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA bTulane University School of Medicine, New Orleans, LA, USA |
| |
Abstract: | Novel effects of naturally occurring peptides are continuing to be discovered, and their mechanisms of actions as well as interactions with other substances, organs, and systems have been elucidated. Synthetic analogs may have actions similar or antagonistic to the endogenous peptides, and both the native peptides and analogs have potential as drugs or drug targets. The journal Peptides publishes many leading articles on the structure–activity relationship of peptides as well as outstanding reviews on some families of peptides. Complementary to the reviews, here we extract information from the original papers published during the past five years in Peptides (1999–2003) to summarize the effects of different classes of peptides, their modulation by other chemicals and various pathophysiological states, and the mechanisms by which the effects are exerted. Special attention is given to peptides related to feeding, pain, and other behaviors. By presenting in condensed form the effects of peptides which are essential for systems biology, we hope that this summary of existing knowledge will encourage additional novel research to be presented in Peptides. |
| |
Keywords: | Peptides Adrenomedullin Amylin Angiotensin Bombesin Bradykinin Cholecystokinin Opioid peptides Ingestive peptides Neurotrophic peptides Feeding Pain Memory Addiction Locomotor activity Electrolyte balance CNS Blood–brain barrier |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|