Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant |
| |
Authors: | Stevens Joanne M Ulrich Ricky L Taylor Lowrie A Wood Michael W Deshazer David Stevens Mark P Galyov Edouard E |
| |
Affiliation: | Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire, UK. |
| |
Abstract: | Recently we identified a bacterial factor (BimA) required for actin-based motility of Burkholderia pseudomallei. Here we report that Burkholderia mallei and Burkholderia thailandensis are capable of actin-based motility in J774.2 cells and that BimA homologs of these bacteria can restore the actin-based motility defect of a B. pseudomallei bimA mutant. While the BimA homologs differ in their amino-terminal sequence, they interact directly with actin in vitro and vary in their ability to bind Arp3. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|