Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides |
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| Authors: | Gerasimova Yuliya V Erchenko Irina A Shakirov Makhmut M Godovikova Tatyana S |
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| Affiliation: | Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 8 Lavrentyev Ave., 630090 Novosibirsk, Russia. |
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| Abstract: | Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Nonenzymatic glycation of HSA decreased the ribonuclease-like activity of the protein. According to (31)P NMR data, both native and glycated albumins induced hydrolysis of RNA molecule through 2',3'-cyclophosphate intermediates. A feasible mechanism of RNA hydrolysis by native albumin and its clinically relevant modification was discussed. |
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