Non-secretion of ABO blood group antigens: a host factor predisposing to recurrent urinary tract infections and renal scarring |
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Authors: | S.J. May C.C. Blackwell R.P. Brettle C.J. MacCallum D.M. Weir |
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Affiliation: | Department of Bacteriology, The Medical School, University of Edinburgh, Edinburgh, Scotland, U.K.;Infectious Diseases Unit, City Hospital, Edinburgh, Scotland, U.K. |
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Abstract: | Abstract In a study of 718 women referred for specialist investigation for recurrent urinary tract infections, 250 (34.8%, P <0.01) were non-secretors. The proportion of non-secretors among the women with renal scars (42.6%) was higher than that found for women with no evidence of renal scars (36.6%). Among 29 patients in whom symptoms began in childhood or adolescence, 51.7% were non-secretors. The proportion of non-secretors among individuals with renal scars in this study (42.6%) and that reported in the accompanying paper for Swedish children (40%) suggests that non-secretion might influence the pathogenic sequelae of these infections. Possible host-parasite interactions underlaying the increased proportion of non-secretors among women with recurrent urinary tract infections and those leading to development of renal scars are discussed. |
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Keywords: | Blood group antigens ABO antigens Urinary tract infection Renal scars |
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