| 异甘草素的合成工艺研究 |
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| 引用本文： | 马永婷,骆浩,李双明,李政楠,付玉杰.异甘草素的合成工艺研究[J].植物研究,2009,29(5):637-640. |
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| 作者姓名： | 马永婷 骆浩 李双明 李政楠 付玉杰 |
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| 作者单位： | (1.东北林业大学林业生物制剂教育部工程研究中心，哈尔滨150040) ;(2.东北林业大学森林植物生态学教育部重点实验室，哈尔滨150040) |
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| 基金项目： | 黑龙江省杰出青年科学基金项目(JC200704,2008.1-2010.12);;科技部“十一五”科技支撑计划(No.2006BAD1880401)资助 |
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| 摘 要： | 以2，4-二羟基苯乙酮和对羟基苯甲醛为原料，通过羟基保护，羟醛缩合及脱保护合成得到了异甘草素。并对其中的关键步骤羟醛缩合反应条件如：催化剂的种类，底物的摩尔比，反应温度，溶剂以及反应时间进行了优化。结果表明，在以Ba(OH)2为催化剂，甲醇为反应溶剂，对羟基苯甲醛和2，4-二羟基苯乙酮的摩尔比为1.8∶1，温度为45℃的条件下，反应12 h，羟醛缩合反应的收率最高（77.9%），且体系较为简单，易于纯化。
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| 关 键 词： | 异甘草素 合成 工艺优化 |
Optimization of Synthesis Process of Isoliquiritigenin |
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| MA Yong-Ting, LUO Hao, LI Shuang-Ming, LI Zheng-Nan, FU Yu-Jie.Optimization of Synthesis Process of Isoliquiritigenin[J].Bulletin of Botanical Research,2009,29(5):637-640. |
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| Authors: | MA Yong-Ting LUO Hao LI Shuang-Ming LI Zheng-Nan FU Yu-Jie |
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| Institution: | 1.Engineering Research Center of Forest Bio-preparation;Ministry of Education;Northeast Forestry University;Harbin 150040;2.Key Laboratory of Forestry Plant Ecology;Harbin 150040 |
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| Abstract: | Isoliquiritigenin was synthesized with 2,4-Dihydroxyacetophenone and 4 Hydroxybenzaldehyde as the starting materials by protecting of hydroxy, Aldol Addition and deprotecting. The reaction conditions of the key step-Aldol Addition, including catalyst, ratio of substrates, temperature, solvent and time were optimized. Results showed that the optimal condition of the key step were as follows: catalyst Ba(OH)2, solvent MeOH, M(4-Hydroxybenzaldehyde):M(2,4-Dihydroxyacetophenone)=1.8∶1, tempetature 45℃, and time 12 h. Under the optimal conditions, the yield of the reaction achieved the highest(77.9%). In addition, the reaction system was simple and easily purified. |
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| Keywords: | isoliquiritigenin synthesis optimization of conditions |
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