Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity |
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Authors: | Alexandre Dal-Pan Stéphane Blanc Fabienne Aujard |
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Institution: | 1.Mécanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique,Muséum National d'Histoire Naturelle,Paris,France;2.Institut Pluridisciplinaire Hubert Curien,UMR 7178 CNRS Université de Strasbourg,Strasbourg,France |
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Abstract: | Background Resveratrol, a natural polyphenolic compound, was shown to protect rodents against high-fat-diet induced diabesity by boosting
energy metabolism. To the best of our knowledge, no data is yet available on the effects of resveratrol in non-human primates.
Six non-human heterotherm primates (grey mouse lemurs, Microcebus murinus) were studied during four weeks of dietary supplementation with resveratrol (200 mg/kg/day) during their winter body-mass
gain period. Body mass, spontaneous energy intake, resting metabolic rate, spontaneous locomotor activity and daily variations
in body temperature were measured. In addition, the plasma levels of several gut hormones involved in satiety control were
evaluated. |
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