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Plasmodium gallinaceum: induction of male gametocyte exflagellation by phosphodiesterase inhibitors. |
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| Authors: | S K Martin L H Miller M M Nijhout R Carter |
| Institution: | Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, U.S.A. |
| Abstract: | The phosphodiesterase inhibitors, Squibb 20009, caffeine, and 8-bromo-cyclic adenosine monophosphate (8-bromo-cAMP) are capable of stimulating gametogenesis, thus implicating cyclic nucleotides in the initiation of this process. Squibb 20009 and 8-bromo-cAMP stimulated gametogenesis at pH 8.0 but not at pH 7.4 whereas caffeine stimulated gametogenesis at pH 8.0 and 7.4. |
| Keywords: | Parasitic protozoa Malaria of birds Gametocyte Exflagellation Gamete Phosphodiesterase inhibitor Cyclic nucleotide Squibb 20009 Caffeine 8-Bromo-cyclic adenosine monophosphate 8-Hydroxy-cyclic adenosine monophosphate Adenosine 3′:5′-monophosphate Dibutyryl cyclic adenosine monophosphate Chicken Mosquito |
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