Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells |
| |
| Authors: | Norton Pamela A Gong Qiaoke Mehta Anand S Lu Xuanyong Block Timothy M |
| |
| Affiliation: | Jefferson Center for Biomedical Research and Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Doylestown, Pennsylvania, USA. pamela.norton@mail.tju.edu |
| |
| Abstract: | An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
