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AFAP1-AS1: a rising star among oncogenic long non-coding RNAs |
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| Authors: | Xiong Fang Zhu Kunjie Deng Su Huang Hongbin Yang Liting Gong Zhaojian Shi Lei He Yi Tang Yanyan Liao Qianjin Yu Jianjun Li Xiaoling Li Yong Li Guiyuan Zeng Zhaoyang Xiong Wei Zhang Shanshan Guo Can |
| Institution: | 1.Science and Technology on Information System Engineering Laboratory, National University of Defense Technology, Changsha, 410000, China ;2.Department of Periodontology, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, 410078, China ;3.NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education of China, Cancer Research Institute, Central South University, Changsha, 410078, China ;4.Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China ;5.Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital Central South University, Changsha, 410011, China ;6.Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA ; |
| Abstract: | Long non-coding RNAs(lnc RNAs) have become a hotspot in biomedical research. This interest reflects their extensive involvement in the regulation of the expression of other genes, and their influence on the occurrence and development of a variety of human diseases. Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1) is a recently discovered oncogenic lnc RNA. It is highly expressed in a variety of solid tumors, and regulates the expression of downstream genes and signaling pathways through adsorption and competing micro RNAs, or by the direct binding to other proteins. Ultimately, AFAP1-AS1 promotes proliferation, chemotherapy resistance, and resistance to apoptosis, maintains stemness, and enhances invasion and migration of tumor cells. This paper summarizes the research concerning AFAP1-AS1 in malignant tumors, including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors. We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research. AFAP1-AS1 is expected to provide an example for studies of other lnc RNA molecules. |
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