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Single-cell transcriptomics of murine mural cells reveals cellular heterogeneity |
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| Authors: | Guan Ya-Na Li Yue Roosan Moom Jing Qing |
| Affiliation: | 1.Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai Jiao Tong University School of Medicine (SJTUSM) & CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai, 200031, China ;2.Chapman University, Irvine, CA, 92618, USA ; |
| Abstract: | Mural cells(MCs) wrap around the endothelium, and participate in the development and homeostasis of vasculature. MCs have been reported as heterogeneous population morphologically and functionally. However, the transcriptional heterogeneity of MCs was rarely studied. In this study, we illustrated the transcriptional heterogeneity of MCs with different perspectives by using publicly available single-cell dataset GSE109774. Specifically, MCs are transcriptionally different from other cell types, and ligand-receptor interactions of different cells with MCs vary. Re-clustering of MCs identified five distinct subclusters. The heterogeneity of MCs in tissues was reflected by MC coverage, various distribution of MC subclusters, and ligand-receptor interactions of MCs and parenchymal cells. The transcriptomic diversity of MCs revealed in this article will help facilitate further research into MCs. |
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