Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells |
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| Authors: | Walos S Szary J Szala S |
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| Affiliation: | Department of Molecular Biology, Center of Oncology-Maria Sk?odowska-Curie Memorial Institute, Gliwice, Poland. |
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| Abstract: | Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10. |
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