Kisspeptins and GPR54--the new biology of the mammalian GnRH axis |
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| Authors: | Aparicio Samuel A J R |
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| Affiliation: | University of Cambridge Department of Oncology, Hutchison-MRC Research Centre, Cambridge CB2 2XZ, United Kingdom. saparicio@bccrc.ca |
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| Abstract: | Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis. |
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