The effect of multivalency on the specificity of protein and cell interactions. |
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Authors: | P H Ehrlich |
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Institution: | Cellular and Molecular Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA |
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Abstract: | The specificity of interaction between proteins and ligands is shown to depend on the multivalency of the interaction. Increases in specificity are possible by increasing the number of protein subunit-ligand interactions. Since there are many receptors on each cell membrane, cells can be considered multivalent and cell-cell interactions can be very specific. |
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