Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide--a potential antileishmanial agent |
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| Authors: | Sahu Niranjan P Pal Chiranjib Mandal Nirup B Banerjee Sukdeb Raha Mausumi Kundu Ashis P Basu Anirban Ghosh Monidipa Roy Keshab Bandyopadhyay Santu |
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| Institution: | Steroid and Terpenoid Chemistry Division, Indian Institute of Chemical Biology, 4 Raja SC Mullick Road, Jadavpur, 700 032, Kolkata, India. npsahu@iicb.res.in |
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| Abstract: | Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug. |
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