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Candida albicans stress mannoproteins expression in superficial and systemic candidiasis |
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| Authors: | Jose Pontón Fernando L Hernando Maria Dolores Moragues Pedro L Barea Mara Gerloni Stefania Conti Paola Fisicaro Cristina Cantelli Luciano Polonelli |
| Institution: | (1) Departamento de Inmunologia, Microbiologia y Parasitología, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Apartado 699, E-48080 Bilbao, Spain;(2) Facultad de Ciencias, Universidad del Pais Vasco, Apartado 699, E-48080 Bilbao, Spain;(3) Departamento de Enfermería I, Universidad del Pais Vasco, Apartado 699, E-48080 Bilbao, Spain;(4) Istituto di Microbiologia, Università degliStudi di Parma, Viole A. Gramsci 14, I-43100 Parma, Italy |
| Abstract: | The presence of heat shock mannoproteins (HSMPs) reactive with sIgA was demonstrated in several C. albicans strains. The subculture of the C. albicans isolated from mucosal surfaces on Sabouraud's dextrose agar at 25 °C switched off the HSMP expression. A re-expression of the HSMPs was obtained in the same medium by shifting the temperature of incubation to 37 °C. However, expression of HSMPs in two strains isolated from deep infections was maintained during several subcultures on Sabouraud's dextrose agar at 25 °C. A glycoprotein of 200 kDa seemed to be the main HSMP reacting with vaginal sIgA. The data presented in this study suggest that factors other than temperature can influence the expression of C. albicans HSMPs and therefore these antigens should be referred as stress mannoproteins.Abbreviations HSMPs heat shock mannoproteins - MAb monoclonal antibody - sIgA secretory IgA |
| Keywords: | Candida albicans heat shock mannoproteins secretory IgA stress mannoproteins |
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