Surface modified dendrimers: synthesis and characterization for cancer targeted drug delivery |
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Authors: | Sharma Anupama Gautam Surya Prakash Gupta Arun Kumar |
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Institution: | Smriti College of Pharmaceutical Education, 4/1, Pipliya Kumar Kakad, Dewas Naka, Indore (M.P.) 452010, India. |
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Abstract: | Dendrimers represents a highly branched three-dimensional structure that provides a high degree of surface functionality and versatility. PAMAM dendrimers are used as well-defined nanocontainers to conjugate, complex or encapsulate therapeutic drugs or imaging moieties. Star-burst PAMAM] dendrimers represent a superior carrier platform for drug delivery. The present study was aimed at synthesis of a surface modified dendrimer for cancer targeted drug delivery system. For this 4.0 G PAMAM dendrimer was conjugated with Gallic acid GA] and characterized through UV, IR, 1H NMR and mass spectroscopy. Cytotoxicity study of dendrimer conjugate was carried out against MCF-7 cell line using MTT assay. The study revealed that the conjugate is active against MCF-7 cell line and might act synergistically with anti-cancer drug and gallic acid-dendrimer conjugate might be a promising nano-platform for cancer targeting and cancer diagnosis. |
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