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Exon level integration of proteomics and microarray data |
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| Authors: | Danny A Bitton Micha? J Okoniewski Yvonne Connolly Crispin J Miller |
| Institution: | (1) Cancer Research UK, Applied Computational Biology and Bioinformatics Group, Paterson Institute for Cancer Research, The University of Manchester,Christie Hospital Site, Wilmslow Road, Manchester, M20 4BX, UK;(2) Cancer Research UK, Proteomics Service, Paterson Institute for Cancer Research, The University of Manchester, Christie Hospital Site, Wilmslow Road, Manchester, M20 4BX, UK |
| Abstract: | BackgroundPrevious studies comparing quantitative proteomics and microarray data have generally found poor correspondence between the two. We hypothesised that this might in part be because the different assays were targeting different parts of the expressed genome and might therefore be subjected to confounding effects from processes such as alternative splicing. |
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