Immunomodulatory effects of <Emphasis Type="Italic">Caulerpa racemosa</Emphasis> var peltata polysaccharide and its selenizing product on T lymphocytes and NK cells in mice |
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Authors: | WeiZai Shen Hui Wang GuoQing Guo JingJing Tuo |
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Institution: | 1.Department of Anatomy, Medical College,Jinan University,Guangzhou,China;2.Ultrasonic Division,Municipal Hospital of Weihai,Shandong,China |
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Abstract: | A polysaccharide, CrvpPS, was isolated from Caulerpa racemosa var peltata. It was reacted with nano-selenium in distilled
water containing ascorbic acid (Vit C) to form a stable CrvpPS-nano-Se complex. The immunomodulatory effects of CrvpPS and
CrvpPS-nano-Se on T lymphocytes subgroups and NK cells in mice were investigated. After intragastric administration for 10
days separately, both CrvpPS and CrvpPS-nano-Se showed significant stimulatory functions to thymus gland of mice. Moreover,
the CrvpPS-nano-Se induced the percentage of CD3
+, CD3
+CD4
+, NK cells and the CD4
+/CD8
+ value to increase significantly (P<0.05) when analyzed by flow cytometry, which is better than the CrvpPS, sucrose-nano-Se, and even the positive drug levamisole. |
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Keywords: | |
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