Early antibody response against <Emphasis Type="Italic">Mycobacterium avium</Emphasis> subspecies <Emphasis Type="Italic">paratuberculosis</Emphasis> antigens in subclinical cattle |
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Authors: | John P Bannantine Darrell O Bayles W Ray Waters Mitchell V Palmer Judith R Stabel Michael L Paustian |
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Institution: | (1) Bacterial Diseases of Livestock Research Unit, USDA/ARS/National Animal Disease Center, Ames, IA 50010, USA |
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Abstract: | Background Our laboratories have previously reported on the experimental infection of cattle with Mycobacterium avium subsp paratuberculosis (M. paratuberculosis) using an intratonsillar infection model. In addition, we have recently developed a partial protein array representing 92
M. paratuberculosis coding sequences. These combined tools have enabled a unique look at the temporal analysis of M. paratuberculosis antigens within the native host. The primary objective of this study was to identify M. paratuberculosis antigens detected by cattle early during infection. A secondary objective was to evaluate the humoral immune response in
cattle during the initial year of infection. |
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