Immunocytochemical study of the relations of acetylcholinesterase,enkephalin-, substance P-, choline acetyltransferase- and calcitonin gene-related peptide-immunoreactive structures in the ventral horn of rat spinal cord |
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Authors: | M Hietanen M Pelto-Huikko L Rechardt |
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Institution: | (1) Department of Biomedical Sciences, University of Tampere, Box 607, SF-33101 Tampere, Finland |
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Abstract: | Summary Calcitonin gene-related peptide (CGRP)-like immunoreactivity was localized immunocytochemically in the large motoneurons in
the ventral horn of rat spinal cord. Using fluorescence double-labelling substance P (SP)-immunoreactive nerve fibres were
found to surround both the CGRP-positive and negative motoneurons, whereas enkephalin (ENK)-immunoreactive fibres surrounded
mainly CGRP-negative cells. All CGRP-like immunoreactive motoneurons were also choline acetyltransferase (ChAT)- and acetylcholinesterase
(AChE)-positive. On the other hand a large population of ChAT- and AChE-positive motoneurons were devoid of CGRP-immunoreactivity.
It is probable that CGRP/ChAT/AChE-positive cells surrounded by SP-positive fibres have different functions in motoric nervous
system than the CGRP-negative ChAT/AChE-positive cells, which are surrounded by ENK-immunoreactive fibres. |
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