高原移居者红细胞滤过指数的变化及其机理

目的：探讨不同海拔和同一海拔高底氧环境不同血色素范围对高原健康人红细胞流变特性的影响及其可能发生的机制。方法：检测不同海拔高度（2260m、3300m、4080m）对320健康人EFI、SOD、和MDA的影响。结果：随海拔高度的升高,高原健康人EFI和MDA含量明显升高,而红细胞SOD活性明显降低;EFI与MDA呈正相关,而与红细胞SOD活性呈负相关。同一海拔低氧环境Hb增高者,EFI和MDA升高,而红细胞SOD活性降低;随海拔升高,EFI和MDA含量明显升高,而红细胞SOD活性明显降低。结论：不同海拔红细胞流变学和氧自由基代谢差异性的形成,低氧环境起核心作用;而随海拔高度升高和同一海拔低氧环境自由基代谢异常加重者是导致高原健康人红细胞流变学异常的中心环节。

Changes of erythrocyte rheology properties in immigrant subjects at different altitudes and its mechanism

Aim: To explore the influence of altitude changes on red blood cell rheology properties and negative effects caused by it and possible mechanism. Methods: Erythrocyte filtration index (EFI), superoxide dismutase (SOD) and Malondialdehyde (MDA) were detected the mechanisms in which EFI changes. Results: EFI increased with increasing altitudes and there was a significant different in EFI at the different range of Hb at the same altitude and a significant different in EFI at the similar range of Hb at different altitudes. Correltive analyses showed that EFI was in a negative correlation with SOD activities, relations between EFI and MDA were on the contraty. Conclusion: Changes of SOD and MDA with increasing altitudes lead to abnormalities of erythrocyte rheology properties in healthy subjects.