Cellular Elements of the Blood-Brain Barrier |
| |
Authors: | Jorge Correale Andrés Villa |
| |
Affiliation: | 1. Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea (FLENI), Monta?eses 2325, 1428, Buenos Aires, Argentina 2. School of Biomedical Sciences, Austral University, Monta?eses 2325, 1428, Buenos Aires, Argentina 3. Department of Neurology, José María Ramos Mejía Hospital, School of Medicine Buenos Aires University, Urquiza 609, 1221, Buenos Aires, Argentina
|
| |
Abstract: | The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is composed of four main cellular elements: endothelial cells (ECs), astrocyte end-feet, microglial cells, and perycites. Transport across the BBB is limited by both physical and metabolic barriers (enzymes, and different transport systems). Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|