Therapeutic applications of adipose-derived stromal vascular fractions in osteoarthritis |
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Authors: | Qi Tang Xian-Sheng Zhao Ao Guo Ruo-Tong Cui Huai-Le Song Zi-Yang Qi Yi Pan Yue Yang Fang-Fang Zhang Liang Jin |
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Affiliation: | Qi Tang, Ao Guo, Ruo-Tong Cui, Huai-Le Song, Zi-Yang Qi, Yi Pan, Yue Yang, Fang-Fang Zhang, Liang Jin, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, ChinaXian-Sheng Zhao, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China |
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Abstract: | Osteoarthritis (OA) is considered to be a highly heterogeneous disease with progressive cartilage loss, subchondral bone remodeling, and low-grade inflammation. It is one of the world's leading causes of disability. Most conventional clinical treatments for OA are palliative drugs, which cannot fundamentally cure this disease. The stromal vascular fraction (SVF) from adipose tissues is a heterogeneous cell population. According to previous studies, it contains a large number of mesenchymal stem cells, which have been used to treat OA with good therapeutic results. This safe, simple, and effective therapy is expected to be applied and promoted in the future. In this paper, the detailed pathogenesis, diagnosis, and current clinical treatments for OA are introduced. Then, clinical studies and the therapeutic mechanism of SVF for the treatment of OA are summarized. |
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Keywords: | Arthritis Articular cartilage Stromal vascular fraction Mesenchymal stem cells Cell therapy |
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| 点击此处可从《World journal of stem cells》浏览原始摘要信息 |
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