Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease |
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| Authors: | Meng-Yue Shi Lian Liu Fu-Yuan Yang |
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| Affiliation: | Meng-Yue Shi, School of Medicine, Yangtze University, Jingzhou 434023, Hubei Province, ChinaLian Liu, Department of Pharmacology, Medical School of Yangtze University, Yangtze University, Jingzhou 434023, Hubei Province, ChinaFu-Yuan Yang, Health Science Center, Yangtze University, Jingzhou 434020, Hubei Province, China |
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| Abstract: | Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis and is an idiopathic, chronic inflammatory disease of the colonic mucosa. The occurrence of IBD, causes irreversible damage to the colon and increases the risk of carcinoma. The routine clinical treatment of IBD includes drug treatment, endoscopic treatment and surgery. The vast majority of patients are treated with drugs and biological agents, but the complete cure of IBD is difficult. Mesenchymal stem cells (MSCs) have become a new type of cell therapy for the treatment of IBD due to their immunomodulatory and nutritional functions, which have been confirmed in many clinical trials. This review discusses some potential mechanisms of MSCs in the treatment of IBD, summarizes the experimental results, and provides new insights to enhance the therapeutic effects of MSCs in future applications. |
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| Keywords: | Mesenchymal stem cells Inflammatory bowel diseases Inflammation Pretreatment Gene editing |
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| 点击此处可从《World journal of stem cells》浏览原始摘要信息 |
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