Shielding of phospholipid monolayers from phospholipase C hydrolysis by alpha-lactalbumin adsorption |
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| Authors: | I Hanssens F H Van Cauwelaert |
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| Affiliation: | Interdisciplinary Research Centre, Katholieke Universiteit Leuven, Campus Kortrijk Belgium |
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| Abstract: | α-Lactalbumin interacts more strongly with lecithin and cardiolipin monolayers at pH 3～4 than at pH 7 to 10. At physiological pH this protein does not penetrate monolayers of DPPC and cardiolipin above pressures of 30 dynes/cm. Enzymatic hydrolysis of these monolayers by phospholipase C (Clostridium Welchii) is inhibited partially or totally when α-lactalbumin is injected in the subphase prior to the enzyme injection. |
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