| 糖尿病大鼠海马中NO含量的变化 |
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| 引用本文： | 陈拥彬,刘德明. 糖尿病大鼠海马中NO含量的变化[J]. 中国组织化学与细胞化学杂志, 2006, 15(4): 468-472 |
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| 作者姓名： | 陈拥彬 刘德明 |
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| 作者单位： | 1. 咸宁学院医学院人体解剖学教研室,咸宁,437100
2. 华中科技大学同济医学院组织胚胎学教研室,武汉,430030 |
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| 摘 要： | 目的观察糖尿病大鼠海马中NOS表达及NO含量的变化,研究糖尿病对海马的影响。方法用Wista大鼠,共24只,随机分成2组,正常组12只,糖尿病组12只,糖尿病组用STZ制模,满12周后,取脑应用生物化学方法、免疫组化及Westernblot技术对大鼠海马进行观察。结果糖尿病组大鼠海马NOS的表达及NO含量较正常组增高(P<0·05)。结论糖尿病可引起海马的病理改变。
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| 关 键 词： | 糖尿病 海马 一氧化氮合酶 一氧化氮 大鼠 |
| 收稿时间： | 2005-10-23 |
| 修稿时间： | 2006-02-10 |
CHANGES OF NO IN THE HIPPOCAMPUS OF DIABETIC RATS |
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| Chen Yongbin,Liu Deming. CHANGES OF NO IN THE HIPPOCAMPUS OF DIABETIC RATS[J]. Chinese Journal of Histochemistry and Cytochemistry, 2006, 15(4): 468-472 |
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| Authors: | Chen Yongbin Liu Deming |
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| Affiliation: | Departmemt of Anatomy, Xianning Medical College, Xianning College, Xianning, 437100; 1 Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Objective To observe the expression of NOS and the changes of NO in the hippocampus of DM rats, in order to study theinfluence of DM on the hippocampus. Methods 24 Wistar rats were randomly divided into two groups: 12 normal rats and 12 rats with STZ DM. 12 weeks later, the biochemical and immunohistochemical methods and Western blot were used to detect changes of NO in the hippocampus. Results NO and NOS in the hippocampus of the DM group was higher than those in the normal group (P<0.05). Conclusion DM may induce pathological changes of the hippocampus. |
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| Keywords: | Diabetes Hippocampus NOS NO Rat |
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