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Biosynthesis of securinine,the main alkaloid of Securinega suffruticosa
Authors:Ushio Sankawa  Yutaka Ebizuka  Kazuo Yamasaki
Institution:1. Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
Abstract:Biosynthesis of securinine was studied by incorporation experiments in Securinega suffruticosa. Among presumed precursors tested, lysine, cadaverine, and tyrosine showed the highest incorporation into securinine. Degradation experiments revealed that cadaverine-1,5-14C] labelled specifically the piperidine ring of securinine and the radioactivity from dl-tyrosine-2-14C] was introduced into the C-11 lactone carbonyl. Experiments with L-tyrosine-U-14C] and L-tyrosine-3′,5′-3H; U-14C] prove that the remaining C6Sz.sbnd;C2 moiety is derived from the aromatic ring and the C-2 and C-3 or tyrosine.
Keywords:Euphorbiaceae  biosynthesis  alkaloid  securinine  tyrosine  cadaverine  
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