S-[2-Carboxy-1-(1H-imidazol-4-yl)ethyl]cysteine in normal human urine |
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| Authors: | M. Kinuta N. Masuoka K. Yao J. Ohta S. Yoshida S. Futani T. Ubuka |
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| Affiliation: | (1) Department of Biochemistry, Okayama University Medical School, 2-5-1 Shikatacho, 700 Okayama, Japan |
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| Abstract: | Summary A compound, which had the same mobility on a high-voltage paper electrophoretogram and the sameRF value on a thin-layer chromatogram as those ofS-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]cysteine (I), was partially purified from human urine by ion-exchange column chromatography. The compound gave a signal at m/z 260 on its FAB mass spectrum, which was assigned as MH+ of compound I. These results suggest that the urinary compound is compound I and it is a physiological precursor of 3-[(carboxymethyl)thio]-3-(1H-imidazol-4-yl)propanoic acid [Kinuta et al., (1991) Biochem J 275: 617–621]. |
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| Keywords: | Amino acids Human urine Paper electrophoresis Cysteine Imidazole compound |
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