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Differential expression of type XIV collagen/undulin by human mammary gland intralobular and interlobular fibroblasts |
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| Authors: | Amanda J Atherton M J Warburton Michael J O’Hare Paul Monaghan Detlef Schuppan Barry A Gusterson |
| Institution: | Department of Surgery, University College Medical School, 67–73 Riding House Street, London W1P 7LD, UK, GB Department of Histopathology, St George’s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK Tel.: 0181 725 5272; Fax: 0181 725 0064; E-mail: mwarburt@sghms.ac.uk, GB Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK, GB Department of Gastroenterology and Hepatology, Klinikum Benjamin Franklin, Free University of Berlin, D-122000 Berlin, Germany, DE |
| Abstract: | Immunolocalisation of type XIV collagen/undulin in the human mammary gland revealed greater deposition in the interlobular stroma than in the intralobular stroma. The interlobular stroma is located between the breast lobules and their associated intralobular stroma. Fibroblasts isolated from the interlobular stroma synthesised 3- to 5-fold more type XIV collagen/undulin than intralobular fibroblasts, but synthesised type I and type IV collagens in similar amounts. The differential expression of type XIV collagen/undulin was maintained with passage in culture. The results suggest a role for type XIV collagen/undulin in stabilising dense collagen fibrils. The maintenance of two types of structurally distinct stromas may be important during developmental processes in the mammary gland. |
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