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The effect of mycophenolic acid on the cell cycle ofCandida albicans |
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| Authors: | Carmel M. Quinn Virginia C. Bugeja Joseph A. Gallagher Peter A. Whittaker |
| Affiliation: | (1) Biology Department, Maynooth College, Maynooth, Ireland;(2) Present address: School of Natural Sciences, Hatfield Polytechnic, Hatfield, Herts., U.K.;(3) Present address: Department of Microbiology, Trinity College, Dublin, Ireland |
| Abstract: | Mycophenolic acid inhibited the growth ofCandida albicans. Cultures exposed to a concentration of 8.4  g ml–1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis.The results are discussed in relation to the possible mode of action of mycophenolic acid. |
| Keywords: | Candida albicans mycophenolic acid cell cycle |
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